PROF. DR. EMEL CANBAY


MD, PhD, FEBS, FACS Emel CANBAY


My Publications



Canbay, E., Norman, M., Kılıç, E., Goffin, V., Zachary, I. ”Prolactin stimulates the JAK2 and focal adhesion kinase pathways in human breast carcinoma T47-D cells, ” Biochem J, 324 ; 231-236 Part 1 (1997)

Canbay, E. ”Erb-B2 homodimerization inhibits MUC1 transcription in cultured human mammary epithelial cells,” Cell Biol. Int., 27(6); 477-481 (2003).

Canbay, E., Dokmetas, S., Canbay, E.I., Sen, M., Bardakci F. ” Higher glutathione transferase GSTM1 0/0 genotype frequency in young thyroid carcinoma patients, ” Curr Med Res Opin, 19(2); 102-106 (2003).

Ugurlu, L., Turan, M., Canbay, E., Elagoz, S., Sen, M. ”Effects of nifedipine on the healing of left colonic anastomoses in rats,” Surg Today, 33(12): 902-908 (2003)

Turan, M., Sen, M., Canbay, E., Karadayi, K., Yildiz, E. “Gastric necrosis and perforation caused by acute gastric dilatation: Report of a case,” Surg Today. 33(4):302-304 (2003)

Karadayi, K., Canbay, E. Turan, M., Gokgoz S, Sen M. ”Acute cholecystitis, obstructive jaundice, pyogenic cholangitis, and acute pancreatitis caused by Ascaris lumbricoides: Report of a case” Chir Gastroenterol, 19(2): 184-186 (2003)

Bardakci, F., Canbay, E., Degerli, N.,Coban, L., Canbay, E.I. “Relationship of tobacco smoking with GSTM1 gene polymorhism in laryngeal cancer.” J Cell Mol Med 7(3); 307-312 (2003)

Turan M, Unver Saraydin S, Canbay E, Karadayi K, Bulut E, Cetinkaya O, Elagoz S, Sen M. Positive effects of phenytoin on experimental colonic anastomoses. Int J Colorectal Dis. 19 (3): 250-257 (2004)

Karadayi, K., Turan, M., Canbay, E., Topcu, O., Sen M. ”Laparascopic versus Open Appendectomy: Analysis of Sistemic Acute-Phase Responses in a Prospective Randomized Study” Chir Gastroenterol, 19(4): 396-400 (2003)

Canbay, E., Degerli, N., Gulluoglu, B., Kaya, H., Sen, M., Bardakci F ” Could prolocatin receptor gene polymorphism play a role in pathogenesis of breast carcinoma? Curr Med Res Opin 20 (4): 533-540 (2004)

Turan M, Saraydın SU, Bulut HE, Elagoz S, Cetinkaya O, Karadayi K, Canbay E, Sen M. ” Do vascular endothelial growth factor and basic fibroblast growth factor promote phenytoin’s wound healing effect in rat? An immunohistochemical and histopathologic study.” Dermatol Surg 30 (10): 1303-1309 (2004)

Topcu O, Canbay E, Turan M, Arici S, Sumer Z, Sen M. “Inflammatory pseudotumor of the sigmoid colon by Enterobius vermicularis: A case report”. Chir Gastroenterol , (2004) 20 (3): 227-229

Puryan K, Karadayi K, Topcu O, Canbay E, Sumer Z, Turan M, Karayalcin K, Sen M. ‘’Chlorhexidine gluconate: an ideal scolicidal agent in the treatment of intraperitoneal hydatidosis?” World J Surg. 29(2):227-30. (2005)

Karabeyoglu MS, Canbay E, Albayrak L, Yildirim O, Unal B, Bozkurt B, Cengiz O. ’’Concurrent ruptured ovarian follicle and appendicitis’’Chirurgische Gastroenterologie 2006

Canbay, E, Gur B, Bozkurt B, Karabeyoğlu M, Unal B, Yildirim O, Cengiz O, Yulug IG ‘’Inhibition of focal adhesion kinase with her-2 targeted antibody Pertuzumab (Omnitarg, 2C4) in breast cancer cells’’ Gene Therapy and Molecular Biology, Vol 12(B), 293-299, 2008

Unal B, Karabeyoglu M, Huner T, Canbay E, Yidirim O, Bilgihan A, Cengiz O. ‘’Ethyl pyruvate protects colonic anastomosis from ischemia reperfusion injury’’accepted for publication at Surgical Innovation, 16(1):21-25, 2009.

Ozmen V, Muslumanoglu ME, Igci A, Canbay E, Ozcinar B, Mudun A, Eralp Y, Saip P, Tuzlali S, Dincer M, Dagoglu T, Kecer M, Parlak M. “Is the sentinel lymph node biopsy accurate for patie.nts with initially clinically axilla-positive locally advanced breast cancer after neoadjuvant chemotherapy? Cancer Research, 69(2): 337S-338S, Suppl., 2009

Ozmen V, Unal ES, Muslumanoglu ME, Igci A, Canbay E, Ozcinar B, Mudun A, Tunaci M, Tuzlali S, Kecer M. “Axillary sentinel node biopsy after neoadjuvant Chemotherapy.” EJSO, 36(1):23-9, 2010.

Canbay E, Bozkurt B, Ergul G, Agrali G, Cengiz O. “Breast Carcinoma with Choriocarcinomatous Features.” Breast Journal, 16(2); 202-3, 2010.

Canbay E, Agachan B, Gulluoglu M, Isbir T, Balik E, Yamaner S, Bulut T, Cacina C, Yaylim Eraltan I,Yilmaz A, Bugra D. Possible Associations of APE1 Polymorphism with Susceptibility and HOGG1 Polymorphism with Prognosis in Gastric Cancer. Anticancer Res. 30(4):1359-64, 2010

Canbay E, Agachan B, Ozturk T, Giris M, Asoglu O, Balik E, Bugra D.Dual inhibition of wound healing and oxidative process by Montelukast in experimental colon anastomoses. Surg Innov. 2010 Sep;17(3):248-55.

Canbay E, Yaylım-Eraltan I, Cercel I, Isbir T, Gazioglu E, Aydogan F, Cacina F, Cengiz A, Ferahman F, Zengin E, Unal H. CCND1 and CDKN1B Polymorphisms and Risk of Breast Cancer. Anticancer Res. 2010 Jul;30(7):3093-8

Bulut T, Canbay E, Yamaner S, Gulluoglu M, Bugra D. ‘’Solitary Rectal Ulcer Syndrome:Exploring Possible management options’’ accepted in International Surgery, 96: 2011

Canbay E, Akman E. ‘’An adult patient presenting with appendix perforation in appendix duplication: case report’’ Journal of Medical Case Reports, 5:162 2011

Canbay E, Agachan B, Gulluoglu M, Balik E, Bulut T, Yamaner S, Zaybek U, Sozen S, Cacina C, Bugra D. Association of APE-1 and HOGG1 polymorphisms with colorectal cancer risk in Turkish population Current Medical Research and Opinion, 1-8, 2011

Canbay E, Ergen A, Bugra D, Yamaner S, Eraltan IY, Buyukuncu Y, Bulut T.Kisspeptin-54 levels are increased in Patients with Colorectal Cancer. World J Surg. 2012 May 3

Mizumoto A, Canbay E, Hirano M, Takao N, Matsuda T, Ichinose M, Yonemura Y. Morbidity and mortality Outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at a single institution in Japan. Gastroenterology Research and Practice. 2012; 2012: 836425

Hirano M, Ozamoto Y, Ichinose M, Togawa T, Matsuda T, Takao N, Mizumoto A, Canbay E, Yonemura Y. Laparoscopic diagnosis and management for pseudomyxoma peritonei from appendiceal neoplasm. Gastroenterology Research and Practice. 2012; 2012: 741202

Ergen A, Canbay E, Bugra D, Zeybek U, Yamaner S, Bulut T. Plasma Kisspeptin-54 levels in gastric cancer patients accepted in International Journal of Surgery, 2012

Canbay E, Kahraman OT, Bugra D, Caykara B, Seyhan MF, Bulut T, Yamaner S, Ozturk O. PTEN IVS4 polymorphism is associated with susceptibility to colorectal cancer in Turkish population accepted for publication in Expert Opinion Therapeutic Targets, 2012

Canbay E, Kurnaz O, Canbay B, Bugra D, Cakmakoglu B, Bulut T, Yamaner S, Sokucu N, Buyukuncu Y, Yilmaz-Aydogan H. PPAR-gamma Pro12Ala polymorphism and gastric cancer risk in a Turkish population. Asian Pac J Cancer Prev. 13(11):5875-8,2012

Canbay E, Ishibashi H, Sako S, Kitai T, Nishino E, Yonemura Y. Late recurrence of benign multicystic peritoneal mesothelioma complicated with an incisional hernia. Case Rep Surg. 2013;2013:903795.

Canbay E, Ishibashi H, Sako S, Mizumoto A, Hirano M, Ichinose M, Takao N, Yonemura Y. Preoperative Carcinoembryonic Antigen Level Predicts Prognosis in Patients with Pseudomyxoma Peritonei Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. World J Surg. 2013 Mar 7

Canbay E, Ishibashi H, Sako S, Kitai T, Nishino E, Hirano M, Mizumoto A, Endo Y, Ogura SI, Yonemura Y. Photodynamic detection and management of intraperitoneal spreading of primary peritoneal papillary serous carcinoma in a man: report of a case. Surg Today. 2013 Feb 23

Yonemura Y, Canbay E, Ishibashi H. Prognostic factors of peritoneal metastases from colorectal cancer following cytoreductive surgery and perioperative chemotherapy. The Scientific World Journal. 18:978394, 2013

Kitai T, Hirai T, Fujita T, Yonemura Y, Canbay E. Survey on the incidence and management of pseudomyxoma peritonei in Japan. Gan To Kagaku Ryoho. 2013 Aug;40(8):1043-8.

Coskunpinar E, Canbay E, Oltulu YM, Tiryakioglu NO, Bugra D. GSTT1 is deregulated in left colon tumors. Asian Pac J Cancer Prev. 2014;15(5):2319-21. PubMed PMID: 24716977.

Canbay E, Yonemura Y, Brucher B, Baik SH, Sugarbaker PH. Intraperitoneal chemotherapy and its evolving role in management of gastric cancer with peritoneal metastases. Chin J Cancer Res. 2014 Feb;26(1):1-3.

Canbay E, Mizumoto A, Ichinose M, Ishibashi H, Sako S, Hirano M, Takao N, Yonemura Y. Outcome data of patients with peritoneal carcinomatosis from gastric origin treated by a strategy of bidirectional chemotherapy prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a single specialized center in Japan. Ann Surg Oncol. 2014 Apr;21(4):1147-52. doi:

Nagata H, Yonemura Y, Canbay E, Ishibashi H, Narita M, Mike M, Kano N. Differentiating a large abdominal cystic lymphangioma from multicystic mesothelioma: report of a case. Surg Today. 2014 Jul;44(7):1367-70.

Liu Y, Endo Y, Fujita T, Ishibashi H, Nishioka T, Canbay E, Li Y, Ogura SI, Yonemura Y. Cytoreductive Surgery Under Aminolevulinic Acid-Mediated Photodynamic Diagnosis Plus Hyperthermic Intraperitoneal Chemotherapy in Patients with Peritoneal Carcinomatosis from Ovarian Cancer and Primary Peritoneal Carcinoma: Results of a Phase I Trial. Ann Surg Oncol. 2014 Jul 24.s



POSTER BİLDİRİLERİ



Canbay E, Goffin V, and Norman M. ”Prolactin stimulates cell proliferation of T47D breast cancer cells, ” Endocrine Society Meeting, J Endocrinol p140, 1994

Canbay E, Goffin V and Norman M . “Mitogenic Response of a Human Breast Cancer Cell Line to Recombinant Human Prolactin.” 13th Joint Meeting British Endocrine Societies, Journal of Endocrinolog, Vol 140, Suppl. P192, Bournemouth, United Kingdom. 21-24 March 1994

Canbay E, Zachary I, Goffin V, Martial J, and Norman M. ”Prolactin Stimulates Cell Proliferation and Tyrosine Phosphorylation of JAK2 in Human Breast Cancer Cell Lines, ” The Biochemical Society Meeting,No:653 p65, 1994 University of Sussex. Brighton,United Kingdom 13-16 December 1994.

Canbay E, Norman M, Farndon J, Goffin V and Zachary I. “Prolactin stimulates thyrosine phosphorylation of p125 Focal Adhesion Kinase (FAK) and Paxillin in Breast Cancer Cells,” International Clinical Endocrinology Congress, The Endocrine Society OR31-3, San Francisco. 12-15 June 1996.

Kilic E, Canbay E, Goffin V, McArdle C and Norman M. “The Proliferative Effect of Prolactin on Breast Cancer Cells:Synergy with Estrogen and Abolation by Anti-Estrogen,” International Clinical Endocrinology Congress, USA. Endo ’98, P1-26,128, 1998

Canbay E. “Homodimerization of ErbB2 Signals Inhibition of Transcription of MUC1 Gene in Mammary Epithelial Cells. First Congress of the World Society for Breast Health”, OP-15, Istanbul,Turkey, 22-25 September 2001

Canbay E. ”Homodimerization of ErbB2 Signals Inhibition of Transcription of MUC1 Gene in Mammary Epithelial Cells” American Society of Clinical Oncology 37thMeeting, Vol 20, Part 1 of 2, Abstract Publication Number1685, San Francisco,CA 12-15 May 2001

Puryan K, Karadayi K, Topcu O, Sumer Z, Canbay E, Turan M, Karayalcin K.“Can Chlorhexidine – Gluconate Be An Ideal Scolocidal Agent In The Treatment Of Intra-Peritoneal-Hydatosis?” 5th European Congress of the IHPBA, p 278, Istanbul –Turkey 28-31 May 2003 (http://www.ihpba2003.org/docs/Posters.doc)

Canbay E., Dokmetas, S., Canbay, E.I., Sen, M., Bardakci, F. ” Higher GSTM1 0/0 genotype frequency in young thyroid carcinoma patients.” American Society of Clinical Oncology 39thMeeting, Abstract Publication Number 3540, Chicago, Illinois 31 May-June 3, 2003

Canbay E, Gur-Dedeoglu B, Bozkurt B, Karabeyoglu M, Unal B, Cengiz O, Yulug I. ‘’Pertuzumab inhibits FAK phosphorylation in breast cancer cells’’. National Surgical Congress, Antalya-Turkey

Ozmen V, Canbay E, Ozçınar B, İğci A, Müslümanoğlu M , Mudun A , Tuzlalı S, Yavuz E, Dağoğlu T , Keçer M , Parlak M. The Clinical Relevance of Internal Mammary Lymph Node Biopsy in San Antonio Breast Congress, December 2008.

Canbay E, Agachan B, Cercel A, ISbir T, Uras C, Celik V, Calay Z, Sozen S, Bagci G, Esen B, Unal H. Polymorphisms of DNA repair genes (XRCC1, XRCC3,XPD, XPG, HOGG1 and APE-1) in Breast Cancer. (poster no:1125) in San Antonio Breast Congress, December 2009.

Canbay E, Agachan B, Gulluoglu M, Isbir T, Balik E,Yamaner S, Bulut T, Zeybek U, Sozen S, Cacina C, Yilmaz A, Bugra D. Association of Colorectal Cancer Development and Prognosis with DNA Repair Genes (poster no: 199) in American Society of Colorectal Surgeon Societes Congress, Minneapolis, 2010

Canbay E, Ergen A, Bugra D, Yamaner S, Eraltan IY, Buyukuncu Y, Bulut T.Kisspeptin Increased serum levels in patients with colorectal cancer (poster no 136). European Surgical Society, Krakow, 2011

Canbay E, Yonemura Y. Upper abdominal peritonectomy procedures (oralpresentation). 66 th Annual Meeting of Japanese Society for Advancement of Surgical Techniques, Fukuoka, , 2012

Canbay E, Ishibashi H, Sako S, Ensei Y, Yonemura Y. Peritoneal dissemination of granulosa cell tumor. Annual Meeting of Japanese Society for Research of LocoRegional Cancer Therapy, Fukushima,2012

Canbay E, Yonemura Y. Safety and survival after cytoreductive surgery with peritonectomy procedures and hyperthermic intraperitoneal chemotherapy. The 11thInternational Congress of Hyperthermic Oncology. Kyoto, 2012

Coskunpinar E, Canbay E, Oltulu Y, Bugra D. Expression of GST T1 is downregulatedin patients with left colon cancers. European Surgical Society, Istanbul, 2012

Canbay E, Yıldız SY, Turgut T, Çiftçi A, Özyıldız M, Boyacıoğlu Z, Gülümser F. Single incision multiport laparoscopic appendectomy. European Surgical Society, Istanbul, 2012

Yonemura Y, Canbay E, Ischibashi H, Ichinose M. Analysis of long-term survivors of patients with peritoneal metastasis after cytoreductive surgery combined with perioperative chemotherapy. 10th International Gastric Cancer Congress, Verona, Italy, 2013

Yonemura Y, Canbay E, Ishibashi H, Endo Y, Ogura S, Ichinose M. 5-Aminolevulinicacid (ALA)-fluorescence guided peritonectomy. 10th International Gastric Cancer Congress, Verona, Italy, 2013

Canbay E. Cytoreductive surgery and HIPEC results from Turkey after Japanese Education. 6th AsianCongressof Hyperthermic Oncology and the 31st Japanese Congress of Thermal Medicine, 2014



POSTER PRESENTATIONS



Canbay E., Değerli, N., Güllüoğlu, B., Kaya, H., Sen, M., Bardakcı, F. Direct Submission Can prolactin receptor polymorphism cause breast cancer ? Submitted 6 Feb 2003. http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=29423968 http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=protein&val=29423969

Book ‘’Atlas and Principles of Peritonectomy for peritoneal surface malignancy’’. Edited by: Yonemura Y, Elnemr A, Li Y, Yang X-J, Chang-Yun L, Miura M, Endo Y, Kitai T, Hsieh M-C, Mizumoto A, Hirano M, Sako S, Ishibashi H, Canbay E. 2011 1st Publisher NPO to support Peritoneal Surface Malignancy Treatment Kobe/Osaka/Kusatsu

Canbay E ”Howmuch are national guidelines followed by the medical centers treating gastric cancer in your country” -Round Table- 10th International Gastric Cancer Congress, 2013